S, epidemiological research to detect associations of gene polymorphisms with illness phenotypes are preferred.
HHS Public AccessAuthor manuscriptBiochim Biophys Acta. Author manuscript; out there in PMC 2016 April 01.Published in final edited form as: Biochim Biophys Acta. 2015 April ; 1855(2): 27600. doi:ten.1016/j.bbcan.2015.03.006.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptInsights in to the essential roles of proteoglycans in breast HSP105 Formulation cancer biology and translational medicineAchilleas D. Theocharis1, Spyros S. Skandalis1, Thomas Neill2, Hinke A. B. Multhaupt3, Mario Hubo4, Helena Frey4, Sandeep Gopal3, Ang ica Gomes3, Nikos Afratis3, Hooi Ching Lim3, John R. Couchman3, Jorge Filmus5, Ralph D. Sanderson6, Liliana Schaefer4, Renato V. Iozzo2, and Nikos K. Karamanos1,1Coccidia drug Biochemistry,Biochemical Analysis Matrix Pathobiology Research Group, Laboratory of Biochemistry, Division of Chemistry, University of Patras, 26500 Patras, Greece2Departmentof Pathology, Anatomy and Cell Biology, along with the Cancer Cell Biology and Signaling Plan, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA of Biomedical Sciences and Biotech Investigation Innovation Center, University of Copenhagen, Denmark3Department4Universityof Frankfurt, Institute of Pharmacology and Toxicology, Theodor-Stern Kai 7, Frankfurt 60590 Germany of Biological Sciences, Sunnybrook Investigation Institute and Department of Health-related Biophysics, University of Toronto, Canada6University5Departmentof Alabama at Birmingham, Department of Pathology, UAB Complete Cancer Center, 1720 2nd Ave. S, WTI 602B, Birmingham, AL 35294, USAAbstractProteoglycans manage quite a few typical and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. In the course of tumor improvement and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes impacts cancer cell signaling, development and survival, cell adhesion, migration and angiogenesis. Regardless of the high complexity and heterogeneity of breast cancer, the speedy evolution in our understanding that proteoglycans are among the essential players within the breast tumor microenvironment suggests their possible as pharmacological targets within this sort of cancer. It has been lately recommended that pharmacological remedy could target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent inside the proteoglycans which will be presented herein provides the prospective for various layers of regulation2015 Published by Elsevier B.V. Corresponding author: Nikos K. Karamanos, address as above, phone: +30-2610-997915, [email protected]. Publisher’s Disclaimer: This can be a PDF file of an unedited manuscript that has been accepted for publication. As a service to our buyers we are offering this early version of your manuscript. The manuscript will undergo copyediting, typesetting, and assessment on the resulting proof just before it is actually published in its final citable type. Please note that through the production approach errors may perhaps be discovered which could influence the content, and all legal disclaimers that apply towards the journal pertain.Theocharis et al.Pageof breast tumor behavior. This overview summarizes current developments regarding the biology of selected proteoglycans in breast cancer, and presents possible.
