In Figure 5. A total of 3 meta-analyses Kinesin-7/CENP-E Purity & Documentation reported the association involving dietary vitamin D intake and RC threat. We discovered a significant and inverse association when considering all of the subjects (0.67 (0.51; 0.87)) or women alone (0.57 (0.39; 0.82); Figure S3A,C, respectively), whereas we reported a non-significant association in men alone (1.03 (0.72; 1.47); Figure S3B). Particular associations in between each supplemental and total vitamin D and RC in women reported non-significant final results (Figure 5A).Cancers 2021, 13,11 ofFigure five. Super plot of (A) case-control and (B) prospective cohort studies assessing the association amongst vitamin D intake (highest versus lowest categories) and the danger of rectal cancer.In a continuous scale, La Vecchia et al. 1997 [17] reported a non-significant association amongst dietary vitamin D intake and RC in all subjects (1.03 (0.9; 1.two)). 3.three. Meta-Analyses of Prospective Cohort Studies 3.3.1. Colorectal Cancer Figure 2B summarized eight meta-analyses and a single independent analysis for the association among dietary intake, supplemental and total vitamin D with CRC incidence in all subjects, and males or ladies separately. The key outcome referred to dietary vitamin D intake in all subjects, and we did not discover a substantial association (0.94 (0.79; 1.11); Figure 3B). Furthermore, we neither reported a CYP4 Source considerable association between dietary vitamin D and CRC in men nor in females alone when comparing intense categories of dietary vitamin D intake (Figure S1C,D, respectively). In the case of supplemental vitamin D, we reported a substantial inverse association with CRC incidence in all subjects (0.80 (0.66; 0.96); Figure S1E) along with the one of a kind study reporting associations in guys (0.65 (0.50; 0.85)), whereas we showed a non-significant association for ladies (Figure S1F). Finally, this inverse association was also observed when evaluating total vitamin D, toward a 20 and 29 protection in case of all subjects (0.80 (0.67; 0.95)) and men (0.71 (0.57; 0.90)), respectively (Figure S1G,H). Nevertheless, no substantial association was reported inside the meta-analysis conducted in ladies (0.96 (0.81; 1.15); Figure S1I).Cancers 2021, 13,12 of3.three.2. Colon Cancer Figure 4B shows the super plot of six individual analyses and 1 meta-analysis for the prospective association in between vitamin D intake and CC incidence. The only study conducted assessing the association among dietary vitamin D and CC in all subjects did not show a considerable connection (1.18 (0.40; 3.47)). This non-significant association was also showed in men and females analyzed separately (Figure S2F). The analyses assessing the association in between either supplemented or total vitamin D in men or ladies analyzed separately didn’t show substantial outcomes. In a continuous scale, Mart ez et al. 1996 reported [18], in women only, a nonsignificant inverse association for each dietary and total vitamin D intake with CC threat (0.96 (0.72; 1.28) and 0.81 (0.63; 1.05), respectively). three.3.three. Rectal Cancer Only dietary vitamin D intake as well as the threat of RC has been evaluated in all subjects, and men or females only. Nevertheless, in all of them non-significant associations were reported when comparing extreme categories of intake. Inside a continuous scale, Mart ez et al. 1996 reported [18], in ladies only, a important association among dietary vitamin D intake and CC threat (0.45 (0.25; 0.83)), in addition to a nonsignificant association when total vitamin D was evaluated (1.16 (0.73; 1.82)). three.4.
