Product Name :
CHIR99021
CAS No.:
252917-06-9
Purity :
> 98%
Shipping:
Shipped on dry ice.
Storage :
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
SMILES:
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Product Description :
CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
Formula:
C22H18Cl2N8
Molecular Weight :
465.34
Synonyms:
Additional Information:
|CAS No. 252917-06-9 ; |Chemical Name 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile ; |Formula C22H18Cl2N8 ; |Molecular Weight 465.{{143851-98-3} site|{143851-98-3} Biological Activity|{143851-98-3} In Vivo|{143851-98-3} custom synthesis} 34 ; |PubChem CID 9956119 ; |SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N ; |Target Cdks ; |Product Description CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.{{815610-63-0} web|{815610-63-0} Purity & Documentation|{815610-63-0} Purity|{815610-63-0} supplier} 7 nM, respectively.PMID:30844170 CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. ; |Format Liquid ; |Purity > 98% ; |Source Synthetic ; |Shipping Shipped on dry ice. ; |Storage Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months. ; |Solubility Overview Soluble in DMSO to 100 mM
