Product Name :
CDC 5-LO inhibitor
Description:
Cinnamyl-3, 4-dihydroxy-α-cyanocinnamate (CDC) is a potent and direct inhibitor of 5-LO (5-Lipoxygenase) that reduces 5-LO activity in cell-free assays. CDC also inhibits 12-LO and 15-LO
CAS:
132465-11-3
Molecular Weight:
321.33
Formula:
C19H15NO4
Chemical Name:
3-Phenyl-2-propen-1-yl (2E)-2-cyano-3-(3, 4-dihydroxyphenyl)-2-propenoate
Smiles :
N#C/C(=C\C1=CC(O)=C(O)C=C1)/C(=O)OC/C=C/C1C=CC=CC=1
InChiKey:
XGHYFEJMJXGPGN-UYHGDYIZSA-N
InChi :
InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Cinnamyl-3, 4-dihydroxy-α-cyanocinnamate (CDC) is a potent and direct inhibitor of 5-LO (5-Lipoxygenase) that reduces 5-LO activity in cell-free assays. CDC also inhibits 12-LO and 15-LO|Product information|CAS Number: 132465-11-3|Molecular Weight: 321.33|Formula: C19H15NO4|Synonym:|CDC|Cinnamyl-3, 4-dihydroxy-α-cyanocinnamate|Chemical Name: 3-Phenyl-2-propen-1-yl (2E)-2-cyano-3-(3, 4-dihydroxyphenyl)-2-propenoate|Smiles: N#C/C(=C\C1=CC(O)=C(O)C=C1)/C(=O)OC/C=C/C1C=CC=CC=1|InChiKey: XGHYFEJMJXGPGN-UYHGDYIZSA-N|InChi: InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in ethanol (5 mg/ml), and DMSO (5 mg/ml).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Osilodrostat} MedChemExpress|{Osilodrostat} Mineralocorticoid Receptor|{Osilodrostat} Purity & Documentation|{Osilodrostat} Description|{Osilodrostat} manufacturer|{Osilodrostat} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Sitagliptin} site|{Sitagliptin} Autophagy|{Sitagliptin} Purity & Documentation|{Sitagliptin} Data Sheet|{Sitagliptin} custom synthesis|{Sitagliptin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further.PMID:36014399 Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport.|In Vivo:|The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3, 4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions.|References:|Wang X, et al. 12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury. J Diabetes Investig. 2019;10(3):639-649.Products are for research use only. Not for human use.|